USING DBname acforum_excellence_test Anticoagulation Centers of Excellence
  

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Resource Center

Disease State Management

Atrial Fibrillation - Stroke Prevention

 2014 AHA/ACC Guideline for the Management of Patients with Atrial Fibrillation    NEW
January CT, Wann LS, Alpert JS, Calkins H, Cleveland JC, Cigarroa JE, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Circulation 2014;129
 2014 Provider Toolkit by the Michigan Anticoagulation Quality Improvement Initiative (MAQI2)    NEW
Created by a consortium of anticoagulation clinics and experts from across the state of Michigan; contains Afib and VTE risk assessment, patient selection, intiation for Warfarin and TSOACs
 AHA Algorithmic Approach to Stroke Prevention in Atrial Fibrillation
 AHA Algorithmic Approach to Stroke Prevention in Atrial Fibrillation and Coronary Stents
 Assessing Stroke & Bleeding Risk in Atrial Fibrillation - Consensus Statement 2012
 CHA2DS2-VASc Online Calculator for Atrial Fibrillation Stroke Risk
 CHA2DS2-VASc validation article (Lip 2010)
 CHADS2 Online Calculator
 CHADS2 Score - Validation Article (Gage 2001)
 Clinical Practice Guideline on Use of Antithrombotics in NVAF July 2014    NEW
17 page guide outlining considerations in deciding between ASA, warfarin and various TSOAC agents from UW Health, July 2014. Includes flow diagram that points providers in the direction of appropriate agents based on patient-specific information.
 Clinical Strategies for Selecting Oral Anticoagulants in Patients with Afib, 8/13    NEW
20 page articleJ Thromb Thrombolysis. 2013 August outlining foundation for drug selection based on clinical trial-derived evidence. Covers pharmacokinetics, pharmacodynamics, metabolism, and drug–drug interactions along with special patient populations. Sean D. Pokorney,Matthew W. Sherwood, Richard C. Becker.
 Efficacy & Safety of New Oral Anticoagulants with Warfarin in Patients with NVAF, The Lancet 3/14    NEW
March 2014 article from The Lancet evaluating new oral anticoagulants with warfarin in patients with NVAF through analysis of randomised trials RE-LY, ROCKET AF, ARISTOTLE, and ENGAGE AF–TIMI by Christian T Ruff , Robert P Giugliano, Eugene Braunwald, Elaine B Hoff man, Naveen Deenadayalu, Michael D Ezekowitz, A John Camm,Jeff rey I Weitz, Basil S Lewis, Alexander Parkhomenko, Takeshi Yamashita, Elliott M Antman
 European Heart Rhythm Society Practical Guide on use of TSOACs in Non-Valvular AFIB
 HAS-BLED Online Bleeding Risk Calculator
 HEMORR2HAGES Risk Assessment Tool
 Preventing AFib Related Strokes Powerpoint
 Stroke Risk Scorecard, National Stroke Association
From the national Stroke Association, assesses risk with action steps

Drug Cost-Related Issues

 Apixaban (Eliquis) link for free 30 day supply and co-pay savings card    NEW
 Apixaban (Eliquis) patient assistance for uninsured or low-income    NEW
 Dabigatran (Pradaxa) Patient Cares Foundation
Boehringer Ingelheim Cares Foundation Patient Assistance Program Web Portal
 Dabigatran (Pradaxa) Patient Savings Card    NEW
Co-pay savings card for commercial insurance holders
 Dalteparin (Fragmin) Injectable LMWH Patient Assistance    NEW
 Enoxaparin (Lovenox) injectable LMWH    NEW
Sanofi Patient Connection; benefit verification,authorization, patient assistance, billing and coding support and claims & appeals
 Enoxaparin (Novartis) Patient Assistance Program
 Medicare Prescription "Extra Help Program" Link 2014
Supplemental Medicare prescription program for patients with resources limited to $13,440 for an individual or $26,860 for a married couple living together as of 2014
 Needy Meds.org
Rx Assistance database of programs; National non-profit organization that maintains a website of free information on programs that help people who can't afford medications and healthcare costs
 Partnership for Prescription Assistance
The Partnership for Prescription Assistance helps qualifying patients without prescription drug coverage get the medicines they need for free or nearly free.
 Prescription Assistance 360 - Patient advocacy clearing house for prescription support
Connect patients to over 270 Patient Assistance Programs through website designed by Patient Advocates, and a single point of contact
 Rivaroxaban (Xarelto)
Guide to financial assistance programs available for XARELTO® including a list of most of the eligibility requirements
 Rivaroxaban (Xarelto) patient assistance for uninsured or low income patients    NEW
A comprehensive support program focused on access, education, and adherence tools
 Rivaroxaban (Xarelto) Savings Card
Co-pay savings card for commercial insurance holders, sample card, rx assist for uninsured or low-income

Patient Self Testing

 Patient Self-Testing Overview, Patient Info Guide (Clot Connect 2013)
7 page document from Clot Connect, 2013 explaining merits of home testing, current devices and considerations for choosing this testing method.
 Patient Self-Testing Presentation, Ansell PowerPoint, Oct 2012
 Patient Self-Testing/Management Consensus Statement AC Forum, 2008
Rationale for Wider Implementation of Patient Self-Testing • Patient Self-Testing Costs and Related Reimbursement • Practical Guidelines for Implementation of Patient Self-Testing • Summary of Consensus Panel Recommendations
 Self Testing; Home Machine Patient Education Material    NEW
10 page brochure from Brigham & Women's Hospital, explaining all aspects of home testing including patient quiz and agreement

Patient Treatment Care Plans

 Anticoagulation Forum Outpatient Consensus Statement 2008
10 page document from the Anticoagulation Forum providing recommendations, policies, and procedures pertaining to the provision of optimized anticoagulation therapy designed to achieve desired clinical endpoints while minimizing the risk of anticoagulant-related adverse outcomes (principally bleeding and thrombosis).
 Antithrombotic Therapy and Prevention of Thrombosis
 Clinical scores to predict recurrence risk of venous thromboembolism    NEW
2012 4-page article from Thrombosis and Haemostasis,Kyrle & Eichinger outlining 3 prediction models to assess recurrance risk of VTE
 Clinical Strategies for Selecting Oral Anticoagulants in Patients with Afib, 8/13    NEW
20 page articleJ Thromb Thrombolysis. 2013 August outlining foundation for drug selection based on clinical trial-derived evidence. Covers pharmacokinetics, pharmacodynamics, metabolism, and drug–drug interactions along with special patient populations. Sean D. Pokorney,Matthew W. Sherwood, Richard C. Becker.
 Delivery of Optimized Inpatient Anticoagulation Therapy: Consensus Statement from the Anticoagulation Forum, May 2013
From the AC Forum, guidelines designed to promote optimization of patient clinical outcomes while minimizing the risks for potential anticoagulation-related errors and adverse events. Table 8 in the article includes a “Care Transitions Checklist”
 How I treat anticoagulated patients undergoing an elective procedure or surgery (Spyropoulos and Douketis, 2012)
Article from Blood outlining risk, strategy and management as it pertains to patients on anticoagulants
 International Society on Thrombosis and Haemostasis 2012 Patient Selection Recommendations
Selection and assessment of patients treated with the novel oral anticoagulant drugs: a recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis
 Managing Multiple Health Problems in Older Adults, Amer. Geri. Society 2012
 Patient Preferences and Values in Antithrombotic Care, CHEST 2012
 Reversal of target-specific oral anticoagulants Deborah M. Siegal, Adam Cuker, May 2014    NEW
6-page article from Drug Discovery Today, May 2014; Summarizes the available evidence for TSOAC reversal using nonspecific and specific reversal agents
 Target Specific Anticoagulants & Patient Selection, ASH 2012
 Transitioning to and from the novel oral anticoagulants: a management strategy for clinicians    NEW
J Thromb Thrombolysis Feb 2014, Elsayed Abo-Salem,Richard Becker 8-page article focuses on transitioning to and from TSOACs employing a practical pharmacokinetic- and pharmacodynamic-based approach.
 Two-Page Summary: Management of Anticoagulation in the Peri-Procedural Period
prepared by IPRO, New York State’s Medicare Quality Improvement Organization (prints best on 11x17 paper)

Pediatric Patient Care

 CHEST 2012 Antithrombotic Therapy in Neonates and Children
2012 CHEST 65 page supplement specifically addressing optimal strategies for the management of thrombosis in neonates and children
 Pediatric Anticoag Guidelines from The Children's Hospital of Philadelphia, 2014
multiple guidelines including anticoagulation medication guidelines for management of pediatric blood clots/thromboembolic disorders created by The Children's Hospital of Philadelphia & Dr. Dr. Leslie Raffini, 2014; Heparin, Enoxaparin & Coumadin included
 PEDIATRIC ENOXAPARIN TREATMENT ORDER
Pediatric Enoxaparin Treatment (Low-Molecular Weight Heparin) order Set from Intermountain Healthcare; note not to be used to treat patients with serious hemorrhagic complications
 Pediatric Hematology Anticoagulation Warfarin Protocol, Vanderbilt 2012
Protocol including dosing, monitoring and reversal of warfarin in pediatrics; created by Robert F. Sidonio, Jr, MD, MSc, Vanderbilt U School of Medicine
 Pediatric Hematology Heparin and Enoxaparin Anticoagulation Protocol, Vanderbilt 2012
Protocol that includes dosing, monitoring and reversal for heparin and enoxaparin and conversion between drugs; 2012;Robert F. Sidonio, Jr,MD,MSc, Vanderbilt U School of Medicine
 Therapeutic Dosing Unfractionated Heparin – Ped. Inpatient Clinical Practice Guideline, UW Health 2012
2012 protocol from UW Health, includes recommendations for dosing, monitoring and dose adjustments for pediatric patients;Sara Shull, PharmD, MBA, Drug Policy Manager, SShull@uwhealth.org ; University of Wisconsin Hospital and Clinics

Special/High-Risk Patient Populations

 Low Molecular Weight Heparins in Special Populations: Renal Impairment and Obesity
 Monitoring LMWH During Pregnancy
Chart from UW Medicine offering guidance for monitoring of LMWHs during 3rd trimester of pregnancy
 Pregnancy-Related Venous Thromboembolism, Jrl of Pharmacy Practice, April 2014    NEW
11 page article in Journal of Pharmacy Practice, April 2014, Emily M. Armstrong, Jessica M. Bellone, Lori B. Hornsby, Sarah Treadway and Haley M. Phillippe
 The Post Thrombotic Syndrome, Vazquez & Kahn 2010
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Specialty Testing/Monitoring

 Acquired Thrombophilia, Jrl of Pharmacy Practice, April 2014    NEW
10 page article exploring Acquired Thrombophilia, including incidence, mechanisms, and implications and treatment;Armstrong,Bellone, Hornsby,Treadway,Phillippe,Jrl of Pharmacy Practice, April 2014
 Heparin-induced thrombocytopenia CHEST 2012
 HIT Pocket Guide ASH 2009
 HIT Risk Stratification and Treatment Protocol, UNMH 2012
 How I treat heparin-induced thrombocytopenia; 10 page article in Blood, 2012, Cuker & Cines    NEW
10 page article covering evaluation and management of patients with heparin-induced thrombocytopenia. Includes methods to minimize misdiagnosis and unnecessary treatment and investigation of ways to improvement of the diagnosis, Jan 2012 Blood
 Pregnancy-Related Venous Thromboembolism, Jrl. of Pharmacy Practice, April 2014    NEW
10 page article outlining risk, incidence, mechanism and treatment; Jrl of Pharmacy Practice, April 2014; Armstrong, Bellone, Hornsby, Treadway, Phillippe
 Sydney Criteria for Thrombophilia Testing
 Thrombophilia (Moll 2009)
 Thrombophilia Screening, Jrl of Pharmacy Practice, April 2014    NEW
8 page article exploring reasons for thrombophilia screening; merits of screening symptomatic and asymptomatic family members & discussion of screening women prior to prescribing COC therapy; Hornsby, Armstrong, Bellone, Treadway, Phillippe, April 2014
 Thrombophilia Testing Chart
 Treatment of HIT (Warkentin 2011) ASH
 Warfarin Pharmacogenetic Testing Resource, 2013
available evidence and existing recommendations as to the use of pharmacogenetic (PG) testing to guide warfarin dosing

Valvular Heart Disease

 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease    NEW
Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP III, Guyton RA, O’Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM III, Thomas JD. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014
 ACCP Guidelines for Valvular Heart Disease, 2012
 European Journal of Cardio-Thoracic Surgery Guidelines on the Management of Valvular Heart Disease 2012

VTE Prevention and Treatment

 Acquired Thrombophilia, Journal of Pharmacy Practice, April 2014    NEW
10 page article outlining Acquired Thrombophilia; Risk Factors, Incidence, Mechanisms, and Implications by Emily M. Armstrong, Jessica M. Bellone, Lori B. Hornsby, Sarah Treadway and Haley M. Phillippe
 Algorithmic Approach to Treating Upper Extremity DVT, AHA 2012
 Algorithmic Approach to VTE Treatment, UW 2010
 Antithrombotic Therapy and Prevention of Thrombosis
 Aspirin for Preventing Recurrence of Unprovoked VTE - AC Forum Webinar
 Clinical scores to predict recurrence risk of venous thromboembolism    NEW
2012 4-page article from Thrombosis and Haemostasis,Kyrle & Eichinger outlining 3 prediction models to assess recurrance risk of VTE
 HIT Pocket Guide, 2009
 Inherited Thrombophilia, Journal of Pharmacy Practice, April 2014    NEW
8-page article exploring common disorders that alter normal hemostasis; April 2014 Journal of Pharmacy Practice; Haley M. Phillippe, Lori B. Hornsby, Sarah Treadway, Emily M. Armstrong and Jessica M. Bellone
 Management of venous thromboembolic diseases & the role of thrombophilia testing (NICE Summary)
UK based National Institute for Health and Care Excellence (NICE)Summary 40 page evidence-based guideline for VTE management
 Outpatient Disease Management of Deep Venous Thrombosis
 Pamphlet on VTE Prevention, 2010
includes information on HIT, Hypercoag, etc.
 Post-Thrombotic Syndrome Visual Assessment Guide
 Recommendations for Air Travel
Overview of how to prevent VTE during travel, and how to diagnose and treat VTE from Cleveland Clinic, Feb, 2011
 The Post Thrombotic Syndrome, Vazquez & Kahn 2010
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 Thrombophlia, April 2014 Journal of Pharmacy Practice    NEW
4 page article in Journal of Pharmacy Practice, April 2014, outlining Thrombophilia and VTE; Charles E. Mahan, Lori B. Hornsby, Allison Burnett, Todd R. Marcy and Susan E. Conway
 VTE Implemetation Toolkit    NEW
Toolkit for implementing and measuring evidence- based vte ppx strategies from Society of Hospital Medicine, 2014
 VTE Prophylaxis Guideline
 VTE Prophylaxis Pocketcard
 Wells' - Criteria for Pulmonary Embolism / PE Online Calculator
 Wells' Criteria for DVT - MD Online Calculator
online calculator of Wells' Score for risk of DVT
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